Osage-Orange prefers open sunny areas and can grow in a variety of soils. Osage-Orange is considered hardy to zone 5. While native to the south-central United States, it is now can be found naturalized south of the Great Lakes and north of Florida (zone 9A), across the whole of eastern North America into the great plains states almost to the Rocky Mountains. Because it was used so extensively in our pioneer days, it can be found along Western settlement trails and old fort locations even in the pacific northwest.